Marina E. Emborg

Director Preclinical Parkinson’s Research Program, Associate Professor, Senior Scientist

Department:

Marina Emborg Medical Physics

Contact Information:

  • (608) 262-9714

Other web pages:

Aligned research focus:

Neurobiology, neurodegenerative disorders

Organ system/disease focus:

Neurobiology

Research description:

My research focuses on understanding and developing treatments for neurological disorders, in particular Parkinson's disease, in a highly collaborative, interdisciplinary fashion. Our studies are guided by the three rules of animal use: refining, reducing and replacing. We aim to create animal models and experimental paradigms that better reflect patients’ clinical conditions. We apply advance imaging techniques to minimize invasive procedures, maximize data collection and create new clinical applications. We search for safe neuroprotective strategies that will prevent, slow down or stop death of brain cells, and use stem cells as model systems and as cell–based strategies. Our goal is to find solutions for neurodegenerative disorders and bring them to the clinic.

Selected references:

Research ethics. Beyond access vs. protection in trials of innovative therapies. London AJ, Kimmelman J, Emborg ME. Science. 2010 May 14;328(5980):829-30.

Intraoperative Intracerebral MRI-Guided Navigation for Accurate Targeting in Nonhuman Primates. Emborg ME, Joers V, Fisher R, Brunner K, Carter V, Ross C, Raghavan R, Brady M, Raschke J, Kubota K, Alexander A. Cell Transplant. 2010;19(12):1587-97.

Response of aged parkinsonian monkeys to in vivo gene transfer of GDNF. Emborg ME, Moirano J, Raschke J, Bondarenko V, Zufferey R, Peng S, Ebert AD, Joers V, Roitberg B, Holden JE, Koprich J, Lipton J, Kordower JH, Aebischer P. Neurobiol Dis. 2009 Nov;36(2):303-11