David Abbott

Professor

Department:

David Abbott Obstetrics and Gynecology

Contact Information:

Curriculum Vitae:

David Abbott's Curriculum Vitae

Other web pages:

Endocrinology & Reproductive Physiology Program

Aligned research focus:

Women’s reproductive health, including obesity and type 2 diabetes mellitus (T2DM) within polycystic ovary syndrome (PCOS)

Organ system/disease focus:

Polycystic ovary syndrome

Research description:

I have more than 30 years of experience employing animal models of female reproductive endocrinology to determine pathophysiological mechanisms underlying a variety of reproductive health disorders commonly found in women. More recently, in collaboration with Dr. Daniel Dumesic (UCLA, Obstetrics and Gynecology), my lab developed a comprehensive nonhuman primate model for polycystic ovary syndrome (PCOS) that was the vanguard for a multitude of animal and human studies aimed at determining developmental origins of this most common endocrinopathy in women. We have translated insight gained from the nonhuman primate model to discern pathophysiological mechanisms causing discrete aspects of reproductive and metabolic dysfunction in women with PCOS, including abnormalities at the molecular level. Our most recent work identifies metabolic dysfunction as possibly the initial abnormality in early developmental origins of PCOS.

Selected references:

Abbott DH, Tarantal AF, Dumesic DA. 2009 Fetal, infant, adolescent and adult phenotypes of polycystic ovary syndrome in prenatally androgenized female rhesus monkeys. Am J Primatol. 71:776-784.

Abbott DH, Bruns CM, Barnett DK, Dunaif A, Goodfriend TL, Dumesic DA, Tarantal AF. 2010 Experimentally-induced gestational androgen excess disrupts glucoregulation in rhesus monkey dams and their female offspring. Am J Physiol Endocrinol Metab. 299:E741-751.

Padmanabhan V, Veiga-Lopez A, Abbott DH, Recabarren S, Herkimer C. 2010 Developmental programming: Impact of prenatal testosterone excess and postnatal weight gain on insulin sensitivity index and transfer of traits to offspring of overweight females. Endocrinology. 151:595-605.